eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
4/2011
vol. 36
 
Share:
Share:
abstract:

Review paper
The genetic determinants of immunologic response in periodontitis

Sylwia Małgorzata Słotwińska

(Centr Eur J Immunol 2011; 36 (4): 275-278)
Online publish date: 2011/12/24
View full text Get citation
 
This article summarizes some experimental and clinical data about genetic aspects of immunologic response in periodontitis. Both the innate and adaptive immunological reactivity can be modified by genetic factors. Many studies have supported the hypothesis of genetic implications in the etiopathogenesis of periodontitis. Genetic polymorphism being emphasized as a distinctively important phenomenon. The particular genotype determines the susceptibility or resistance to periodontal disease. The HLA molecules play a significant role in the progress of immunological response by presenting bacterial antigens to the effector cells of the immune system. On the basis of many studies a genetic test was developed, embracing the polymorphism of genes encoding cytokines and their receptors. Patients carrying the allele 2 of IL-1β gene are six times more prone to periodontal diseases as compared to the allele 1 of IL-1β gene. So, we can expect the new therapeutic protocols.
keywords:

periodontitis, host response, immune system, genetic determinants

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.