eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
2/2011
vol. 15
 
Share:
Share:
abstract:
Original paper

Concentration of vasoactive intestinal polypeptide, neuropeptide Y and calcitonin gene related peptide in neoplastic tissue of the human large intestine

Janusz Godlewski
,
Zenon Pidsudko
,
Waldemar Sienkiewicz

Contemporary Oncology (2011) vol. 15; 2 (65–68)
Online publish date: 2011/04/29
View full text Get citation
 
PlumX metrics:
Aim of the study: The purpose of this study was to investigate the presence of vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY) and calcitonin gene related peptide (CGRP) neuropeptides in neoplastic tissue of the large intestine. The results obtained were compared to an unchanged part of the intestine originating from the same patient.

Material and methods: The tissue samples were taken from the postoperative part of the intestine, resected during an operation due to treatment of colon cancer. Tissues were taken from 15 patients. Concentrations of neuropeptides were determined by ELISA tests, and results were calculated per 1 γ of fresh tissue. The data obtained were statistically analysed.

Results: In tissues of the neoplastic tumour of the sigmoid colon and rectum the concentration of VIP and NPY was determined (28.9 ng/g and 8.6 ng/g, respectively). The observed values were statistically significantly lower than those observed in corresponding tissues of unchanged intestinal segments (83.9 ng/g for VIP and 19.5 ng/g for NPY). Surprisingly, amounts of CGRP were very similar in both neoplastic and intact tissues (13.3 ng/g and 13.4 ng/g respectively).

Conclusions: Immunoenzymatic investigations allow one to establish the concentration of neuropeptides associated with the enteric nervous system in cancer tissues of the large intestine. Various concentrations of these neuropeptides were observed in particular patients of both compared groups. The performed statistical analysis did not reveal associations between degree of cancer infiltration within the colonic wall and the level of presence of investigated neuropeptides in either cancer or control tissues. The fact of presence of these neuropeptides in cancer tissues confirmed by this study should be underlined at the same time.
keywords:

colon cancer, enteric nervous system, neuropeptides, calcitonin gene related peptide, neuropeptide Y, vasoactive intestinal polypeptide

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.