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Folia Neuropathologica
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Original paper

Down-regulation of PGAM5 attenuates spinal cord injury-induced neuronal injury by inhibiting ASK-1/p38/NF-kB signaling

Junjie Guan
1
,
Xin Xu
2
,
Runze Zhang
2
,
Yingchu Gu
2
,
Xiangdong Chen
1

  1. Affiliated Hospital of Nantong University, Nantong, China
  2. Medical College of Nantong University, Nantong, China
Folia Neuropathol 2024; 62
Online publish date: 2024/07/10
Article file
- Down-regulation.pdf  [1.45 MB]
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1. Ashammakhi N, Kim HJ, Ehsanipour A, Bierman RD, Kaarela O, Xue C, Khademhosseini A, Seidlits SK. Regenerative therapies for spinal cord injury. Tissue Eng Part B Rev 2019; 25: 471-491.
2. Chen J, Wang Q, Zhou W, Zhou Z, Tang PY, Xu T, Liu W, Li LW, Cheng L, Zhou ZM, Fan J, Yin GY. GPCR kinase 2-interacting protein-1 protects against ischemia-reperfusion injury of the spinal cord by modulating ASK1/JNK/p38 signaling. FASEB J 2018: fj201800548.
3. Chen Y, Gong K, Guo L, Zhang B, Chen S, Li Z, Quanhua X, Liu W, Wang Z. Downregulation of phosphoglycerate mutase 5 improves microglial inflammasome activation after traumatic brain injury. Cell Death Discov 2021; 7: 290.
4. Chen Y, Gong K, Xu Q, Meng J, Long T, Chang C, Wang Z, Liu W. Phosphoglycerate mutase 5 knockdown alleviates neuronal injury after traumatic brain injury through drp1-mediated mitochondrial dysfunction. Antioxid Redox Signal 2021; 34: 154-170.
5. Cheng M, Lin N, Dong D, Ma J, Su J, Sun L. PGAM5: A crucial role in mitochondrial dynamics and programmed cell death. Eur J Cell Biol 2021; 100: 151144.
6. Cowan H, Lakra C, Desai M. Autonomic dysreflexia in spinal cord injury. BMJ 2020; 371: m3596.
7. Dai WL, Bao YN, Fan JF, Li SS, Zhao WL, Yu BY, Liu JH. Levo-corydalmine attenuates microglia activation and neuropathic pain by suppressing ASK1-p38 MAPK/NF-kappaB signaling pathways in rat spinal cord. Reg Anesth Pain Med 2020; 45: 219-229.
8. Ding MJ, Fang HR, Zhang JK, Shi JH, Yu X, Wen PH, Wang ZH, Cao SL, Zhang Y, Shi XY, Zhang HP, He YT, Yan B, Tang HW, Guo DF, Gao J, Liu Z, Zhang L, Zhang SJ, Zhang XJ, Guo WZ. E3 ubiquitin ligase ring finger protein 5 protects against hepatic ischemia reperfusion injury by mediating phosphoglycerate mutase family member 5 ubiquitination. Hepatology 2022; 76: 94-111.
9. He GW, Gunther C, Kremer AE, Thonn V, Amann K, Poremba C, Neurath MF, Wirtz S, Becker C. PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury. Gut 2017; 66: 716-723.
10. He Z, Zou S, Yin J, Gao Z, Liu Y, Wu Y, He H, Zhou Y, Wang Q, Li J, Wu F, Xu HZ, Jia X, Xiao J. Inhibition of endoplasmic reticulum stress preserves the integrity of blood-spinal cord barrier in diabetic rats subjected to spinal cord injury. Sci Rep 2017; 7: 7661.
11. Hewson DW, Bedforth NM, Hardman JG. Spinal cord injury arising in anaesthesia practice. Anaesthesia 2018; 73 Suppl. 1: 43-50.
12. Jiang C, Li Z, Wu Z, Liang Y, Jin L, Cao Y, Wan S, Chen Z. Integrated bioinformatics analysis of hub genes and pathways associated with a compression model of spinal cord injury in rats. Med Sci Monit 2020; 26: e927107.
13. Karsy M, Hawryluk G. Modern medical management of spinal cord injury. Curr Neurol Neurosci Rep 2019; 19: 65.
14. Lee BB, Cripps RA, Fitzharris M, Wing PC. The global map for traumatic spinal cord injury epidemiology: update 2011, global incidence rate. Spinal Cord 2014; 52: 110-116.
15. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402-408.
16. Mathys H, Davila-Velderrain J, Peng Z, Gao F, Mohammadi S, Young JZ, Menon M, He L, Abdurrob F, Jiang X, Martorell AJ, Ransohoff RM, Hafler BP, Bennett DA, Kellis M, Tsai LH. Single-cell transcriptomic analysis of Alzheimer’s disease. Nature 2019; 570: 332-337.
17. Orr MB, Gensel JC. Spinal cord injury scarring and inflammation: therapies targeting glial and inflammatory responses. Neurotherapeutics 2018; 15: 541-553.
18. Smith JA, Das A, Ray SK, Banik NL. Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Res Bull 2012; 87: 10-20.
19. Wang M, Pan W, Xu Y, Zhang J, Wan J, Jiang H. Microglia-mediated neuroinflammation: a potential target for the treatment of cardiovascular diseases. J Inflamm Res 2022; 15: 3083-3094.
20. Wang Y, Bi Y, Xia Z, Shi W, Li B, Li B, Chen L, Guo L. Butylphthalide ameliorates experimental autoimmune encephalomyelitis by suppressing PGAM5-induced necroptosis and inflammation in microglia. Biochem Biophys Res Commun 2018; 497: 80-86.
21. Yan P, Wu X, Liu X, Cai Y, Shao C, Zhu G. A causal relationship in spinal cord injury rat model between microglia activation and EGFR/MAPK detected by overexpression of microRNA-325-3p. J Mol Neurosci 2019; 68: 181-190.
Copyright: © 2024 Mossakowski Medical Research Centre Polish Academy of Sciences and the Polish Association of Neuropathologists. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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