Fetal aortic intima-media thickness as an early predictor of preeclampsia in patients with pregestational diabetes

Daniel Boroń; Jakub Kornacki; Paweł Gutaj; Ewa Wender-Ożegowska; Barbara Więckowska

doi:10.5114/pcard.2024.141443

eISSN: 2449-6731
ISSN: 2449-6723

Prenatal Cardiology

Current issue Archive About the journal Editorial board Abstracting and indexing Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

1/2024

Send email

Copy url:

abstract:

Research paper

Fetal aortic intima-media thickness as an early predictor of preeclampsia in patients with pregestational diabetes

Daniel Boroń

^{1, 2}

,

Jakub Kornacki

¹

,

Paweł Gutaj

¹

,

Ewa Wender-Ożegowska

¹

,

Barbara Więckowska

³

Department of Reproduction, Poznań University of Medical Sciences, Poznań, Poland
Doctoral School, Poznań University of Medical Sciences, Poznań, Poland
Department of Computer Science and Statistics, Poznań University of Medical Sciences, Poznań, Poland

Prenat Cardio 2024

DOI: https://doi.org/10.5114/pcard.2024.141443

Online publish date: 2024/07/30

View full text Get citation

PlumX metrics:

Introduction:
The objective was to evaluate the potential of etal aortic intima-media thickness (aIMT) as a reliable predictor of preeclampsia (PE) in patients with pregestational diabetes (PGDM). Additionally, we aimed to investigate whether intima-media thickening occurs before abnormalities are detected in Doppler examination assessments.

Material and methods:
A nested case-control study was conducted, involving 81 patients with pregestational diabetes in a singleton pregnancy. The patients were categorised into the PE group and controls based on the pregnancy outcome. Ultrasound scans were performed at regular hospital appointments during the 26^th-28^th and 32^nd-34^th gestational week. Based on the aIMT, we developed a ROC curve with AUC (95% CI) = 0.83.

Results:
Patients with an increased aIMT exhibited a more than 6-fold higher risk of PE, with an odds ratio (OR) (95% CI) of 6.56 (1.98, 21.76). The thickening of the intima-media complex is a form of subclinical vascular adaptation to increased placental resistance and can be observed before abnormalities in Doppler.

Conclusions:
Our study suggests an increased aIMT represents indirect evidence of hyperkinetic fetal circulation/elevated fetal blood pressure. Bearing that in mind, it is vital to consider PE as a cardiovascular condition of the mother and the fetus because it affects the future cardiovascular risk in both cases.

keywords:

Fetal aortic intima-media thickness as an early predictor of preeclampsia in patients with pregestational diabetes

Daniel Boroń 1, 2 , Jakub Kornacki 1 , Paweł Gutaj 1 , Ewa Wender-Ożegowska 1 , Barbara Więckowska 3

diabetes, fetal programming, intima media thickness, IMT, preeclampsia, prediction, ultrasound, vasculopathy, vascular programming

Daniel Boroń

^{1, 2}

,

Jakub Kornacki

¹

,

Paweł Gutaj

¹

,

Ewa Wender-Ożegowska

¹

,

Barbara Więckowska

³