eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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2/2003
vol. 28
 
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abstract:

Human monocytes/macrophages in the antitumour response of the host

Anna Szaflarska
,
Maciej Siedlar
,
Marek Zembala

(Centr Eur J Immunol 2003; 28(2): 88–103)
Online publish date: 2004/01/20
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Abstract
Monocytes/macrophages play a significant role in the host’s response to tumours. This includes: cytotoxic/cytostatic activity, presentation of tumour-associated antigens and induction of specific anticancer response of lymphocytes. Circulating blood monocytes respond to a gradient of chemoattractants produced by the tumour, migrate out from the blood to the tumour bed and form a large part of the cellular infiltrate as tumour infiltrating macrophages (TIM). Monocytes and macrophages produce a large array of factors (cytokines, reactive oxygen and nitrogen intermediates, growth factors, prostacyclins, ect.) with opposing biological activities. Consequently, TIM exhibit both tumour growth promoting and inhibitory activities. Furthermore, tumour-derived molecules also modulate TIM activity. In some circumstances monocytes/macrophages are involved in the metastatic process. This review summarizes the current state of knowledge in this area indicating that in fact macrophage-tumour interactions are quite complicated and a delicate balance exists between antitumour response and protumour effect of TIM and the suppression of TIM activity by the tumour. The clinical implications of these findings are also discussed.
keywords:

monocytes/macrophages, tumour cells, cytokines, cytotoxic mediators, tumour infiltrating macrophages, immunotherapy

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