eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
4/2013
vol. 38
 
Share:
Share:
abstract:

Relationship between -238A/G and -308A/G polymorphisms in the promoter region of TNF-α and susceptibility to gout in the Chinese Han male population

Shiguo Liu
,
Hui Wang
,
Changgui Li

(Centr Eur J Immunol 2013; 38 (4): 449-453)
Online publish date: 2013/12/30
View full text Get citation
 
PlumX metrics:
The study has investigated whether -238A/G and -308A/G polymorphisms in the promoter region of TNF-α are associated with susceptibility to gout in the Chinese Han male population. Two hundred and thirty eight gout patients and 263 gout-free controls were enrolled. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the genotypes and allelic frequencies of TNF-α-238A/G and -308A/G. No statistically significant difference was found in the genotypes (for TNF-α-238A/G, χ2 = 1.741, DF = 1, p = 0.187, OR = 0.646, 95% CI: 0.336-1.241; for TNF-α-308A/G, χ2 = 1.893, DF = 2, p = 0.388) or allelic frequencies (for TNF-α-238A/G, χ2 =

= 1.669, DF = 1, p = 0.196, OR = 1.520, 95% CI: 0.802-2.882; for TNF-α-308A/G, χ2 = 0.032, DF = 1,

p = 0.857, OR = 0.957, 95% CI: 0.590-1.552) of TNF-α-238A/G and -308A/G polymorphisms between patients and controls. The -238A/G and -308A/G polymorphisms in the promoter region of TNF-α are not associated with susceptibility to gout and thus do not play a major role in the development of gout in the Chinese Han male population.
keywords:

TNF-α, polymorphism, gout, Han Chinese

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.