Secondary metabolites, spectra characterization,
and antioxidant correlation analysis
of the polar and nonpolar extracts
of Bryophyllum pinnatum (Lam) Oken

Chinyere E. Okafor; Ikechukwu K. Ijoma; Chiamaka A. Igboamalu; Chinaza E. Ezebalu; Chukwuemeka F. Eze; Jessica C. Osita-Chikeze; Chisom E. Uzor; Adaugo L. Ekwuekwe

doi:10.5114/bta.2024.139752

eISSN: 2353-9461
ISSN: 0860-7796

BioTechnologia

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abstract:

RESEARCH PAPERS

Secondary metabolites, spectra characterization, and antioxidant correlation analysis of the polar and nonpolar extracts of Bryophyllum pinnatum (Lam) Oken

Chinyere E. Okafor

¹

,

Ikechukwu K. Ijoma

²

,

Chiamaka A. Igboamalu

¹

,

Chinaza E. Ezebalu

¹

,

Chukwuemeka F. Eze

¹

,

Jessica C. Osita-Chikeze

¹

,

Chisom E. Uzor

¹

,

Adaugo L. Ekwuekwe

¹

Department of Pure and Industrial Chemistry, Chukwuemeka Odumegwu Ojukwu University, Uli, Nigeria
Department of Pure and Industrial Chemistry, Nnamdi Azikiwe University, Awka, Nigeria

BioTechnologia vol. 105(2) ∙ pp. 121–136 ∙ 2024

DOI: https://doi.org/10.5114/bta.2024.139752

Online publish date: 2024/06/25

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EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Okafor C, Ijoma I, Igboamalu C, et al. Secondary metabolites, spectra characterization,
and antioxidant correlation analysis
of the polar and nonpolar extracts
of Bryophyllum pinnatum (Lam) Oken. BioTechnologia. 2024;105(2):121-136. doi:10.5114/bta.2024.139752.

APA

Okafor, C., Ijoma, I., Igboamalu, C., Ezebalu, C., Eze, C.,  & Osita-Chikeze, J. et al. (2024). Secondary metabolites, spectra characterization,
and antioxidant correlation analysis
of the polar and nonpolar extracts
of Bryophyllum pinnatum (Lam) Oken. BioTechnologia, 105(2), 121-136. https://doi.org/10.5114/bta.2024.139752

Chicago

Okafor, Chinyere E., Ikechukwu K. Ijoma, Chiamaka A. Igboamalu, Chinaza E. Ezebalu, Chukwuemeka F. Eze, Jessica C. Osita-Chikeze,  and Chisom E. Uzor et al. 2024. "Secondary metabolites, spectra characterization,
and antioxidant correlation analysis
of the polar and nonpolar extracts
of Bryophyllum pinnatum (Lam) Oken". BioTechnologia 105 (2): 121-136. doi:10.5114/bta.2024.139752.

Harvard

Okafor, C., Ijoma, I., Igboamalu, C., Ezebalu, C., Eze, C., Osita-Chikeze, J., Uzor, C.,  and Ekwuekwe, A. (2024). Secondary metabolites, spectra characterization,
and antioxidant correlation analysis
of the polar and nonpolar extracts
of Bryophyllum pinnatum (Lam) Oken. BioTechnologia, 105(2), pp.121-136. https://doi.org/10.5114/bta.2024.139752

MLA

Okafor, Chinyere E. et al. "Secondary metabolites, spectra characterization,
and antioxidant correlation analysis
of the polar and nonpolar extracts
of Bryophyllum pinnatum (Lam) Oken." BioTechnologia, vol. 105, no. 2, 2024, pp. 121-136. doi:10.5114/bta.2024.139752.

Vancouver

Okafor C, Ijoma I, Igboamalu C, Ezebalu C, Eze C, Osita-Chikeze J et al. Secondary metabolites, spectra characterization,
and antioxidant correlation analysis
of the polar and nonpolar extracts
of Bryophyllum pinnatum (Lam) Oken. BioTechnologia. 2024;105(2):121-136. doi:10.5114/bta.2024.139752.

PlumX metrics:

Oxidative stress-related pathologies have guided the scientific community into delving into natural product-based research on plant-based metabolites. Plant secondary metabolites serve as a valid alternative in managing oxidative stress-related pathologies. In this study, we present the secondary metabolite constituents of the polar extract (PE) and nonpolar extract (NPE) from the leaves of Bryophyllum pinnatum. These constituents were determined through qualitative and quantitative phytochemical screening. The functional groups and structures of these metabolites were determined based on FTIR and GC-MS experiments, respectively. Antioxidant and free radical scavenging (FRS) activities were determined using standard methods, including phosphomolybdenum, FRAP, DPPH, HRSA, and reducing power assays, with comparisons made to the ascorbic acid (AA) standard. Through Pearson correlation analysis, we estimated the relationship between antioxidant and FRS activities. The DPPH results revealed IC50s of 380.104 ± 0.001, 16.763 ± 0.001, and 7.684 ± 0.003 μg/mL for NPE, AA, and PE, respectively, indicating a trend of PE > AA > NPE. However, all other experiments showed a trend of AA > PE > NPE in antioxidant and FRS activities. These results showed the potential antioxidant and FRS properties of both PE and NPE. Additionally, the correlation analysis indicated a strong positive correlation between the antioxidant and FRS activities of PE and NPE. The research results suggest high antioxidant and FRS activities of PE and validate the use of B. pinnatum in managing free radical-related pathologies.

keywords:

Secondary metabolites, spectra characterization, and antioxidant correlation analysis of the polar and nonpolar extracts of Bryophyllum pinnatum (Lam) Oken

Chinyere E. Okafor 1 , Ikechukwu K. Ijoma 2 , Chiamaka A. Igboamalu 1 , Chinaza E. Ezebalu 1 , Chukwuemeka F. Eze 1 , Jessica C. Osita-Chikeze 1 , Chisom E. Uzor 1 , Adaugo L. Ekwuekwe 1

spectrophotometry, correlation, ethnomedicine, phytochemical, absorbance

Chinyere E. Okafor

¹

,

Ikechukwu K. Ijoma

²

,

Chiamaka A. Igboamalu

¹

,

Chinaza E. Ezebalu

¹

,

Chukwuemeka F. Eze

¹

,

Jessica C. Osita-Chikeze

¹

,

Chisom E. Uzor

¹

,

Adaugo L. Ekwuekwe

¹