Mycotic corneal ulcers caused by Fusarium spp.- available therapeutic options

Ewelina Trojacka; Justyna Izdebska; Marta Wroblewska; Beata Sulik-Tyszka; Karolina Ciepiaszuk; Jacek P. Szaflik

doi:10.5114/ko.2021.107300

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ISSN: 0023-2157

Klinika Oczna / Acta Ophthalmologica Polonica

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3/2021
vol. 123

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abstract:

Review paper

Mycotic corneal ulcers caused by Fusarium spp.- available therapeutic options

Ewelina Trojacka

¹

,

Justyna Izdebska

^{1, 2}

,

Marta Wroblewska

^{3, 4}

,

Beata Sulik-Tyszka

^{3, 4}

,

Karolina Ciepiaszuk

^{1, 2}

,

Jacek P. Szaflik

¹

Independent Public Clinical Ophthalmology Hospital in Warsaw, Poland
Chair and Department of Ophthalmology, II Faculty of Medicine, Medical University of Warsaw, Poland
Department of Microbiology of the Central Clinical Hospital, University Clinical Center of the Medical University of Warsaw, Poland
Department of Dental Microbiology, Medical University of Warsaw, Poland

KLINIKA OCZNA 2021, 123, 3: 108–113

DOI: https://doi.org/10.5114/ko.2021.107300

Online publish date: 2021/10/13

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Fungal corneal ulcers caused by Fusarium spp. are known as sight threatening infection with bad course.

Fungus properties, diagnostic difficulties and limited therapeutic ways result in poor outcomes.

Three of antimycotic drugs are effective against Fusarium spp.: natamycin, amphotericin B and voriconazole. Natamycin is the only drug approved by FDA (Food and Drug Administration) for treatment of corneal ulcers caused by Fusarium spp.

Fungistatic work and limited ocular penetration of antimycotic drugs lead to therapeutic keratoplasty in cases with extremely bad course. Patient with recurrent infections and very advanced inflammation, require enucleation.

keywords:

Mycotic corneal ulcers caused by Fusarium spp.- available therapeutic options

Ewelina Trojacka 1 , Justyna Izdebska 1, 2 , Marta Wroblewska 3, 4 , Beata Sulik-Tyszka 3, 4 , Karolina Ciepiaszuk 1, 2 , Jacek P. Szaflik 1

corneal ulcer, Fusarium spp, natamycin, voriconazole, therapeutic penetrating keratoplasty

Ewelina Trojacka

¹

,

Justyna Izdebska

^{1, 2}

,

Marta Wroblewska

^{3, 4}

,

Beata Sulik-Tyszka

^{3, 4}

,

Karolina Ciepiaszuk

^{1, 2}

,

Jacek P. Szaflik

¹